Perturbation of membrane microdomains in GLC4 multidrug-resistant lung cancer cells − modification of ABCC1 (MRP1) localization and functionality
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چکیده
منابع مشابه
Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells.
Multidrug resistance (MDR) is a barrier to successful cancer chemotherapy. Although MDR is associated with overexpression of ATP-binding cassette (ABC) membrane transporters, mechanisms behind their up-regulation are not entirely understood. The cleaved form of the Notch1 protein, intracellular Notch1 (N1(IC)), is involved in transcriptional regulation of genes. To test whether Notch1 is involv...
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15 صفحه اولThe MRP1/ABCC1 Multi-drug Transporter Protein and Cancer
The ultimate cause of treatment failure for many forms of malignant and infectious diseases is the development of resistance to a broad range of cytotoxic drugs. Hence, despite significant advances in cancer treatment, multidrug resistance (MDR) remains a major clinical problem and leads to limited therapeutic options and poor patient outcome in a number of cancers, including high-risk neurobla...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2007
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2007.05688.x